Title Study of somite segmentation mechanism to determin abnormal spinal column development
Authers Kazuo ARAKI and Hiroyuki OKAMOTO
Keywords Somite, spinal column, segmentation, mutant
Citation Bull. Fish. Res. Agen. No.26, 1-8, 2008
Abstract
In the nursery production field, the frequent occurrence of abnormal spinal cord development and curved bodies in fishflies is a big problem. In fish, osteoblasts are bone cells from the sclerotome derived from a somite and they form into sclerofragments and attach to the notochord to form the spinal cord. The analysis of the phenotypes of zebrafish and medaka mutants having irregular somite development showed that irregular somite generation and segmentation induces irregular spinal cord development. However, the mechanism underlying somite segmentation has not been clarified. In this paper, we report our recent study about the detection and functional analysis of genes that control somite segmentation.
URI http://www.fra.affrc.go.jp/bulletin/bull/bull26/araki.pdf