Title The ‘ coupled-oscillators’ in the zebrafish segmentation clock
Authers Hiroyuki Takeda
Keywords somitogenesis, zebrafish, oscillators, clock, Notch
Citation Bull. Fish. Res. Agen. No.26, 9-14, 2008
The most unique feature of vertebrate segmentation is its strict periodicity which is governed by the segmentation clock consisting of numerous cellular oscillators. These cellular oscillators, driven by a negative-feedback loop of Hairy transcription factor, are linked through Notch-dependent intercellular coupling and display the synchronous expression of clock genes. Combining our transplantation experiments in zebrafish with mathematical simulation, we have examined how the cellular oscillators maintain the synchrony and how they form a robust system against developmental noise such as stochastic gene expression and active cell-proliferation. Accumulated data demonstrated that the segmentation clock behaves as a ‘ coupled oscillators’, a mechanism that is used for a synchronous flashing of fireflies.
URI http://www.fra.affrc.go.jp/bulletin/bull/bull26/takeda.pdf