Title Heat shock transcription factors: regulators of cellular stress response in fish
Authers Nobuhiko OJIMA and Michiaki YAMASHITA
Keywords fishes, gene expression regulation, heat-shock response, heat shock transcription factor, Oncorhynchus mykiss
Citation Bull. Fish. Res. Agen. No.26, 35-39, 2008
Fish are exposed to various environmental stressors such as temperature shifts, chemical contaminants, and low dissolved oxygen levels. In particular, adaptation to temperature shifts is essential for the survival of fish, which are poikilothermic animals. Thus, we have studied the molecular basis of the heat shock response in fish. Meanwhile, all organisms respond to high temperatures by inducing the expression of heat shock proteins (HSPs). Transcriptional activation of the eukaryotic HSP genes is regulated by heat shock transcription factors(HSFs), which bind to the heat shock element(HSE) in the upstream region of HSP genes. The HSF family consists of four members, HSF1-4, in vertebrates. In fish species, the expression of HSF1 and HSF2 genes has been detected in rainbow trout and zebrafish. New insights into the function of HSF family members have recently obtained from knockout mice that lack genes of the family. Here, we briefly review recent findings on the function and the activation mechanism of mammalian HSF, and we also review our studies on HSF1 in rainbow trout.
URI http://www.fra.affrc.go.jp/bulletin/bull/bull26/ojima.pdf