Title Molecular cloning of raldh2 from Takifugu rubripes
Authers Susumu UJI, Tadahide KUROKAWA and Tohru SUZUKI
Keywords vitamin A, early development, malformation, metabolic pathway of vitamin A, raldh2
Citation Bull. Fish. Res. Agen. No.26, 41-46, 2008
Embryonic development of organs and tissues in viviparous organisms such as mammals, particularly organs such as the central nervous system, heart and skeletons, is dependent upon vitamin A supplemented from the mother. Conversely, in fish, which are oviparous, embryogenesis is entirely dependent on nutrients stored mainly as yolk within eggs during vitellogenesis. It is therefore possible that abnormalities in seed production by broodstock may arise during embryogenesis in an aquacultural setting due to vitamin A deficiency or hypervitaminosis. The authors hypothesize that, not only is vitamin A metabolism essential to the development of mature female fish, but vitamin A transfer to the eggs is essential for healthy seed production. Here we review the role of vitamin A in mammals and fish. In addition, we describe the molecular characteristics and gene expression patterns in Takifugu rubripes retinaldehyde dehydrogenase 2 (raldh2), which converts retinal to retinoic acid, an active form of vitamin A that controls the mRNA expression of various genes involved in embryogenesis.
URI http://www.fra.affrc.go.jp/bulletin/bull/bull26/uji.pdf