Title Molecular mechanism of androgen action in fish
Authers Koichiro GEN, Hiromi OKU, Takahiro MATSUBARA
Keywords 11-ketotestosterone, androgen biosynthesis, androgen receptor, gonad
Citation Bull. Fish. Res. Agen. No.26, 123-128, 2008
Androgens are pleiotropic hormones for expression of the male phenotype. They play pivotal roles during male sex differentiation, but also during the development of secondary male characteristics and during initiation and maintenance of spermatogenesis. The biological action of androgens is mediated through the androgen receptors (AR), which are ligand-inducible transcription factors. In teleost fishes, an understanding of the molecular mechanism underlying androgen action is important not only for basic science but also for aquaculture. In this article, recent progress in several aspects of androgen action in teleosts is reviewed ; namely, physiological roles, biosynthesis pathway, and structure and function of androgen receptor. Additionally, possible future directions of study are suggested.
URI http://www.fra.affrc.go.jp/bulletin/bull/bull26/gen.pdf